Protein Details: P2X purinoceptor 1

Protein ID

ICDB_Pro_0584

Protein Name

P2X purinoceptor 1

Gene Name

P2rx1

Organism

Mus musculus (Mouse)

Length

399 amino acids

AlphaFoldDB

AF-P51576-F1-model_v4.pdb

Function

ATP-gated nonselective transmembrane cation channel permeable to potassium; sodium and with relatively high calcium permeability (By similarity). Furthermore; CTP functions as a weak affinity agonist for P2RX1 (By similarity). Plays a role in male fertility; bladder contraction and platelet aggregation. Specifically; plays an important role in neurogenic contraction of smooth muscle of the vas deferens; and therefore is essential for normal male reproductive function. In addition; contributes to smooth muscle contractions of the urinary bladder. On platelets; contributes to platelet activation and aggregation and thereby; also to thrombosis. On neutrophils; it is involved in chemotaxis and in mitigating the activation of circulating cells.

Sequence

MARRLQDELSAFFFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFVYEKGYQTSSGLISSVSVKLKGLAVTQLQGLGPQVWDVADYVFPAHGDSSFVVMTNFIMTPQQAQGHCAENPEGGICQDDSGCTPGKAERKAQGIRTGNCVPFNGTVKTCEIFGWCPVEVDDKIPSPALLHEAENFTLFIKNSISFPRFKVNRRNLVEEVNGTYMKKCLYHKILHPLCPVFSLGYVVRESGQDFRSLAEKGGVVGITIDWECDLDWHVRHCKPIYQFHGLYGEKNLSPGFNFRFARHFVQNGTNRRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKFKYAEDMGPGEGERDPAATSSTLGLQENMRTS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 68; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 70; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 70; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 140; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 186; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 186; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 286; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 290; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 290; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 292; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 292; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 309; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 309; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000250|UniProtKB:F8W463"

Disease

Location

Expressed in smooth muscle of the bladder and arteries

DOI ID

10.1126/science.1112014; 10.1371/journal.pbio.1000112; 10.1038/sj.bjp.0703720; 10.1038/47495; 10.4049/jimmunol.0804007; 10.1182/blood-2014-04-571679

RefSeq

NP_032797.3